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lumefantrine will lessen the level or impact of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.armodafinil will lower the extent or impact of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. The efficacy of hormonal contraceptives can be